Copper Gluconate
Also known as Copper di-D-gluconate, Cupric gluconate, Copper(II) gluconate
“CIR Expert Panel says: safe as used in cosmetics.”
Copper Gluconate received a 'safe as used' verdict from the CIR Expert Panel for Cosmetic Ingredient Safety in March 2025 (Final Report, FR_CopperGluconate_032025). The assessment found it non-genotoxic, non-irritating, and non-sensitizing in human repeat-insult patch tests at concentrations up to 0.2%. Maximum reported cosmetic use is 0.008% in leave-on products. The EU does not restrict its use in cosmetics, and it has FDA GRAS status.
Skin-conditioning agent with wound-healing and anti-aging properties attributed to copper's role in collagen synthesis and superoxide dismutase activity
Non-genotoxic in Ames test and chromosomal aberration assays (CIR Final Report, 2025)
Copper-impregnated materials have demonstrated antimicrobial properties; trace copper in leave-on products may offer incidental antimicrobial benefit
- · Copper is an essential trace element but can be cytotoxic at elevated concentrations; cosmetic use levels (≤0.36%) are well below systemic concern thresholds
- · No sensitization signals detected in HRIPTs at concentrations up to 0.2%, though occupational exposure at higher concentrations may warrant caution
Safety Assessment of Copper Gluconate as Used in Cosmetics — Final Report (CIR Expert Panel, March 2025)
“The Expert Panel for Cosmetic Ingredient Safety concluded that Copper Gluconate is safe in cosmetics in the present practices of use and concentration described in this safety assessment.”— FR_CopperGluconate_032025.pdf, Conclusion section