TheDose

Dipotassium Phosphate

Also known as Dipotassium Hydrogen Phosphate, Dibasic Potassium Phosphate, Potassium Phosphate Dibasic, K2HPO4

CIRPubMed

Safe

CIR Expert Panel says: safe as used in cosmetics.”

The CIR Expert Panel assessed Phosphoric Acid and its salts (31 ingredients, including Dipotassium Phosphate) and concluded they are safe in present cosmetic practices when formulated to be non-irritating. Dipotassium Phosphate (dibasic, K2HPO4, CAS 7758-11-4) is assessed in the same group report (IJT 40(S1):34-85, 2021) as Potassium Phosphate (monobasic) and Tripotassium Phosphate; the dibasic form is explicitly named in the QRT row. Independent ingredient-specific toxicology studies in cosmetic contexts are sparse for this common inorganic pH-buffer salt.


Effective pH buffer in cosmetic formulations

Stabilizes emulsion and solution systems

Mineral salt with established safety record in food and pharmaceutical applications


Concerns
  • · Must be formulated to be non-irritating; concentrated phosphate solutions can cause irritation at high pH

CIR Expert Panel
Approved
Safe when formulated to be non-irritating
[1]
CIR Expert Panel · Sep 1, 2022Live

CIR Quick Reference Table (September 2022) — DIPOTASSIUM PHOSPHATE row: Finding=SQ, Citation=IJT 40(S1):34-85;2021

Dipotassium Phosphate | SQ | The CIR Expert Panel concluded that the following 31 ingredients are safe in the present practices of use and concentration in cosmetics as described in this safety assessment, when formulated to be non-irritating...Dipotassium Phosphate... | IJT 40(S1):34-85;2021QuickReferenceTable_AllConclusionTypes.pdf, p. 178
Verificationpdf_textView source
[2]
CIR Expert Panel · Jul 1, 2021

Safety Assessment of Phosphoric Acid and Its Salts as Used in Cosmetics

Verificationweb_textView source
Sources
2
PubMed citations
1
Evidence quality
limited
Last verified
Re-reviewed when a new CIR / SCCS opinion publishes.