TheDose

Pyrus Malus (Apple) Fruit Extract

Also known as Apple Fruit Extract, Malus Domestica Fruit Extract, Apple extract

CIRPubMed

Safe

CIR Expert Panel says: safe as used in cosmetics.”

The CIR Expert Panel reviewed 26 apple-derived ingredients in the 2016 Final Report (republished in IJT 42(1S):36S-56S, 2023; PMID 36809230) and concluded that 21 of them — including Pyrus Malus (Apple) Fruit Extract — are Safe Qualified (SQ) in cosmetic use when formulated to be non-irritating and non-sensitizing. Reported maximum use concentrations are up to 9% in leave-on products (apple fruit water) and 0.8% in rinse-off products (apple fruit extract). Five preparations (apple root extract, apple stem extract, apple callus culture extract, apple oil, and one other) had insufficient data and received an Insufficient (I) verdict. A 2000 double-blind clinical trial (PMID 11194183) of 1% topical procyanidin B-2 (an oligomeric apple polyphenol) applied to scalp for 6 months in 29 subjects reported no adverse side effects in either treatment or control groups. A 2020 randomized placebo-controlled trial (PMID 32294883, n=65 healthy women) of oral apple polyphenol supplementation demonstrated significant prevention of UV-induced facial pigmentation over 12 weeks with no reported adverse events.


CIR-assessed Safe Qualified (SQ) for cosmetic use in the 2016 Final Report (republished IJT 42(1S):36S-56S, 2023) — covers 21 apple-derived ingredients with reported use up to 9% leave-on (fruit water) and 0.8% rinse-off (fruit extract)

Polyphenol antioxidant content: flavan-3-ols (catechin, epicatechin), flavonols (quercetin and glycosides), procyanidin oligomers, and dihydrochalcones (phloridzin) — supports antioxidant cosmetic claims

Naturally contains malic acid (an alpha-hydroxy acid) at trace-to-modest levels in fruit extracts, contributing to mild keratolytic / skin-conditioning effects

Topical procyanidin B-2 (a major apple polyphenol) at 1% applied for 6 months in a 29-subject double-blind clinical trial showed measurable hair-growth effects with no adverse events reported

Plant: Pyrus malus L. / Malus domestica Borkh. (Rosaceae family, pome fruit); the fruit extract differs in safety verdict from root and stem extracts of the same species per the 2016 CIR assessment


Concerns

CIR's SQ verdict requires formulation to be non-irritating and non-sensitizing — formulators must verify their finished product against irritation/sensitization endpoints, particularly given variable polyphenol content across extraction methods and apple cultivars

Pyrus Malus (Apple) Root Extract and Pyrus Malus (Apple) Stem Extract received Insufficient (I) verdicts in the same 2016 CIR assessment — the favorable Fruit Extract verdict does NOT extend to these other anatomical preparations

Apple polyphenols include quercetin, catechins, epicatechin, procyanidin B-2, and dihydrochalcones (phloridzin); skin penetration of these constituents is generally low (Quercetin specifically has poor solubility limiting dermal penetration), so topical bioactivity may be modest at typical use concentrations

Variable composition by cultivar, ripeness, peel-vs-flesh ratio, and extraction solvent (water, glycerin, propylene glycol, ethanol) — the CIR assessment covers the named INCI category but individual extract batches may differ substantially in polyphenol profile and any safety-relevant trace constituents


CIR Expert Panel
Approved
Safe in the present practices of use and concentration as described in the safety assessment, when formulated to be non-irritating and non-sensitizing.
[1]
CIR Expert Panel · Sep 1, 2022Document match

CIR Quick Reference Table (September 2022) — Pyrus Malus (Apple) Fruit Extract row: Finding=SQ, Citation=Final Report 4/2016 Available fr…

Pyrus Malus (Apple) Fruit Extract | SQ | The CIR Expert Panel concluded that the following 21 apple-derived ingredients are safe in the present practices of use and concentration as described in this safety assessment, when formulated to be non-irritating and non-sensitizing...Pyrus Malus (Apple) Fruit Extract... | Final Report 4/2016 Available from CIRQuickReferenceTable_AllConclusionTypes.pdf, Pyrus Malus (Apple) Fruit Extract section
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[2]
Peer-reviewed (PubMed) · Feb 21, 2023

Safety Assessment of Apple-Derived Ingredients as Used in Cosmetics

Verificationweb_textView on PubMed
[3]
Peer-reviewed (PubMed) · Dec 1, 2000

Investigation of topical application of procyanidin B-2 from apple to identify its potential use as a hair growing agent

Verificationweb_textView on PubMed
[4]
Peer-reviewed (PubMed) · Apr 13, 2020

Administration of Apple Polyphenol Supplements for Skin Conditions in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Clini…

Verificationweb_textView on PubMed
Sources
4
PubMed citations
3
Evidence quality
moderate
Last verified
Re-reviewed when a new CIR / SCCS opinion publishes.