Saccharomyces Camellia Sinensis Leaf Cladosiphon Okamuranus Rice Ferment Filtrate
Also known as Hadasei-3, Tatcha ferment filtrate, Green tea / algae / rice triple ferment filtrate
“No regulator has issued a verdict on this ingredient.”
SACCHAROMYCES/CAMELLIA SINENSIS LEAF/CLADOSIPHON OKAMURANUS/RICE FERMENT FILTRATE is a proprietary multi-substrate ferment filtrate trademarked as Hadasei-3 by Tatcha, produced by fermenting green tea leaf (Camellia sinensis), Okinawa algae (Cladosiphon okamuranus), and rice with Saccharomyces yeast. No CIR safety assessment exists for this composite INCI; it does not appear in the October 2024 CIR Quick Reference Table. The individual substrate Cladosiphon Okamuranus Extract carries a standalone CIR finding of S (Safe, Final Report 09/2019), and Camellia sinensis leaf-derived ingredients are assessed safe when formulated to be non-sensitizing (CIR/IJT 2019, PMID 31840549). A 2025 study (PMID 40989892) using Saccharomyces/Rice Ferment Filtrate (a closely related two-substrate ferment) demonstrated significant reduction of advanced glycation end products (AGEs) and antioxidant competitive binding activity, supporting anti-aging efficacy. A 2023 systematic review (PMID 38140115) documents that fermented plant extracts (including Saccharomyces-fermented Camellia sinensis) exhibit antioxidant, anti-inflammatory, anti-melanogenic, and antimicrobial dermal activities. No specific toxicity or sensitization concerns have been identified in the literature for this composite ingredient.
Saccharomyces/Rice Ferment Filtrate component demonstrated significant reduction of skin advanced glycation end products (AGEs) in vitro and ex vivo
Antioxidant activity: SRFF competitively binds to AGE crosslinking sites, reducing skin yellowing and stiffness associated with glycation-linked aging
Camellia sinensis leaf-derived ingredients are well-established as antioxidant and skin conditioning agents; CIR-assessed safe for cosmetic use
Cladosiphon okamuranus (Okinawa mozuku algae) extract has standalone CIR S-rating (Final Report 09/2019); rich in fucoidan, a sulfated polysaccharide with documented moisturizing and anti-inflammatory properties
Fermented plant extracts using Saccharomyces cerevisiae show antimicrobial, antioxidant, anti-inflammatory, anti-melanogenic, and wound-healing activities in peer-reviewed review
Fermentation bioconversion of green tea catechins may increase bioavailability and reduce molecular weight barriers to skin penetration
- · No CIR safety assessment on file for this composite INCI as of October 2024
- · Proprietary Tatcha blend — exact composition, substrate ratios, and fermentation conditions are not publicly disclosed
- · Ferment-derived complex mixture; residual yeast proteins could pose sensitization risk in individuals with yeast allergy (theoretical, not documented in literature)
- · No long-term in vivo human safety data available in public literature for the specific composite ingredient