Xylitylglucoside

Also known as Xylityl Glucoside, Xylitylglucoside

One peer-reviewed human skin study (PMID 36541033, Skin Research and Technology, 2023) explicitly tested a formulation containing xylitylglucoside–anhydroxylitol–xylitol and found significant reductions in skin roughness amplitude and plateau height after 8 hours of application, supporting its humectant efficacy. No dedicated safety toxicology studies were found in PubMed for xylitylglucoside as a standalone ingredient. Industry-supplied data cited in the 2021 CIR saccharide humectants report noted no skin irritation in rabbit OECD TG 404 testing and no sensitization in a maximization test for the Aquaxyl complex (which contains 35–50% xylitylglucoside), but these data were not assessed by the CIR for xylitylglucoside directly. CIR has not issued a standalone safety assessment for xylitylglucoside as of the QRT (12/2017 revised 07/2018) or in subsequent published final reports reviewed.